ENDOTHELIUM’S STATE IN THE EVENT OF ELECTRICAL INJURY

Lyubin Anton Viktorovich, Applicant, sub-department of anaesthesiology, resuscitation and intensive care, Chita State Medical Academy (Chita, 39a Gorkogo str.), paginacia@mail.ru
Shapovalov Konstantin Gennad'evich, Doctor of medical sciences, head of sub-department of anaesthesiology, resuscitation and intensive care, Chita State Medical Academy (Chita, 39a Gorkogo str.), Shkg26@mail.ru

616-001.21: 616.017.1

The purpose of the paper is studying the function of endothelium in the damaged area of a vascular bed after exposure to electric current. The authors have investigated some indicators of endothelial dysfunction in 20 patients with electric trauma. The number of circulating endothelial cells in blood was counted by the method of flowing cytometry by means of «Cytomics FC-500» (Beckman Coulter, the USA) device. Determination of nitrites in blood was carried out by an indirect method (Golikov P. P., et al, 2004). It has been established that in the event of elec-tric injury the quantity of circulating endothelial cells increase by 30 %; the produc-tion of nitrites in blood decrease by 1,8 times. Increasing of cells quantity of endo-thelium in blood appears to be a direct consequence of vessel wall damage by elec-tric current and is inevitably accompanied by the development of endothelial dys-function. An important pathogenetic part of this process is depression of production and secretion of nitrogen oxide – the major vascular regulatory factor of endothelial genesis. Thus, the influence of electric current caused the determined disturbances of endothelium function.

electrotrauma, nitric oxide, moving endothelium cells, endothelium dysfunction.

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